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KMID : 0861120120160020113
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Korean Journal of Oriental Preventive Medicine
2012 Volume.16 No. 2 p.113 ~ p.124
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Inhibitory Effects of Bupleuri Radix on ox-LDL induced Foam Cell Formation
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Lee Hye-Jin
Bae Ho-Sung
Hwang Bang-Yeon
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Abstract
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Oxidized LDL(oxLDL) is captured into macrophage and stimulates to form macrophage foam cell. And it can induce an inflammation and smooth muscle proliferation in atherosclerotic plaque. Objective : In this study, we aimed to investigate the effect of Bupleuri radix(SH) on the foam cell formation, a critical initiation stage of atherosclerosis. Methods : To achieve the goal, we examined the effect of SH on LDL oxidation, nitric oxide production in RAW264.7, and the effect of SH on cupuric sulfate-induced cytotoxicity, LDH release, and macrophage activity. Results : SH inhibited the formation of oxidized LDL from native LDL in RAW264.7 cell culture, and decreased the release of LDH from cupric sulfate-stimulated RAW264.7 cell. In other experiments, SH activated RAW264.7 cell, and prolonged the survival time, and inhibited foam cell formation induced by oxLDL in Raw 264.7 cells. Conclusion : These results showed that SH might prevent atherosclerosis by controlling the early stages of foam cell formation.
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KEYWORD
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atherosclerosis, Bupleuri radix, LDL oxidation, foam cell, macrophage
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